Caging Targets for Destruction

CRL4 Targets CHK1 for PCNA-Independent Destruction

Newest Targets for Anticonvulsant Agents: An Overview

Epilepsy is a neurological condition characterized by recurrent seizures influencing about 1% of the worldwide population. Despite much progress in understanding the pathogenesis of epilepsy, the molecular basis of human epilepsy still remains unclear. Common approaches for pharmacotherapy of epilepsy are still directed towards controlling the symptoms and suppression of seizures. Clinical use ...

From Caging to Grasping

This paper digs into the relationship between cages and grasps of a rigid body. In particular, it considers the use of cages as waypoints to grasp an object. We introduce the concept of pregrasping cages, caging configurations from which an object can be grasped without first breaking the cage. For two-fingered manipulators, all cages are pregrasping cages and, consequently, useful waypoints to...

Caging helps proteins fold.

H ow do proteins fold spontaneously? The quest to answer this question has led to significant developments on theoretical, experimental, and computational fronts in the last decade (1–7). A combination of approaches has provided a detailed understanding of the nature of pathways and the transition states that the polypeptide chain encounters as it traverses the rugged energy landscape. Even as ...

Caging and Uncaging Genetics

It is important for biology to understand if observations made in highly reductionist laboratory settings generalise to harsh and noisy natural environments in which genetic variation is sorted to produce adaptation. But what do we learn by studying, in the laboratory, a genetically diverse population that mirrors the wild? What is the best design for studying genetic variation? When should we ...